| Nr |
10 (Research article) |
| Authors |
Chivian, Dylan; Kim, David; Malmström, Lars; Schonbrun, Jack; Rohl, Carol; Baker, David |
| Title |
Prediction of CASP6 structures using automated Robetta protocols. |
| Journal |
Proteins (2005) Suppl 7 157-66 |
| DOI |
10.1002/prot.20733 |
| Citations |
193 citations (journal impact: 3.42) |
| Abstract |
The Robetta server and revised automatic protocols were used to predict structures for CASP-6 targets. Robetta is a publicly available protein structure prediction server httprobetta.bakerlab.org that uses the Rosetta de novo structure prediction method. We incorporated some of the lessons learned in the CASP-5 experiment into the server prior to participating in CASP-6. We additionally tested new ideas that were amenable to full-automation with an eye towards improving the server. We find that the Robetta server shows the greatest promise for the more challenging targets. The most significant finding from CASP-5 that automated protocols can be roughly comparable in ability with the better human-intervention predictors is repeated here in CASP-6. Proteins 2005. c 2005 Wiley-Liss Inc. |